On February 17, 2026, the JEMINI project published a review titled “Gut microbiome and obesity care: Bridging dietary, surgical, and pharmacological interventions” in Cell Reports Medicine.
JEMINI aims to better understand the complex relationships between the duodenal-jejunal microbiome, immunometabolic status, dietary and lifestyle factors, and the underlying mechanisms.
Since the first studies suggesting an influence of the gut microbiota on various factors associated with obesity in the 2000s, understanding of the mechanisms involved has advanced considerably.
In this review, the authors summarize these numerous findings and provide a state-of-the-art overview of:
– changes in the gut microbiome and their links to metabolic health,
– the obesogenic environment and the microbiome
– microbial mechanisms in energy homeostasis and metabolism
– the emerging role of the microbiome of the upper small intestine
– therapeutic interventions targeting the microbiome-metabolome axis
- Davide Masi, Sorbonne Université – Inserm, Sapienza University of Rome
- Mikiko Watanabe, Sapienza University of Rome
- Karine Clément, Sorbonne Université – Inserm, AP-HP