GLIOBIOTA

• Overall objectives 

Glioblastoma is a particularly aggressive primary brain tumor associated with a poor prognosis and still largely insufficient treatment options. Despite recent advances, current strategies most often fail to control the disease in the long term. In this context, the objective of the GLIOBIOTA project is to explore and characterize the influence of the microbiome and diet on tumor progression and mechanisms of resistance to anticancer treatments.

• Scientific and societal issues

The key objective of GLIOBIOTA is to deepen our understanding of the mechanisms involved in the development and therapeutic resistance of glioblastoma, which remain largely unknown to this day. Particular attention will be paid to the role of the microbiome and the impact of dietary exposure on the progression of this cancer, which has a very poor prognosis. The integration of these factors, particularly through the consideration of diet and targeted modulation of the gut microbiota, could ultimately pave the way for new prevention strategies and innovative therapeutic approaches that will benefit patients.

• Project focuses

The GLIOBIOTA project focuses on three main axes:

1. Characterization of the microbiota-gut-brain axis in glioblastoma
2. Modulation of the microbiome in glioblastoma progression and therapeutic resistance
3. Role of the dietary exposome in glioblastoma